Carlo Brugnara, MD, a Professor of Pathology at Harvard Medical School and Director of the Haematology Laboratory at Boston Children’s Hospital, Boston, MA, USA. Dr. Brugnara is a fellow of the American Society of Clinical Investigation, the Association of American Physicians, and the Academy of Clinical Laboratory Physicians and Scientists. Since 2007 he is the Editor-in-Chief of the American Journal of Hematology. Dr. Brugnara’s clinical laboratory-based research has been focused on the use of hematological parameters to assess the balance between iron availability and erythropoiesis. He has described the appearance of functional iron deficiency in normal subjects treated with recombinant human erythropoietin (r-HuEPO) based on the particular flow cytometric characteristics of erythrocytes and reticulocytes. He has shown the clinical value of reticulocyte parameters in the setting of r-HuEPO use and in the diagnosis of iron deficiency in children.